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Lumbar Spine Surgery

Lumbar Fusion: PLF, TLIF, XLIF/LLIF & ALIF

Stabilizing a painful or unstable level, and how the different approaches compare.

Written and medically reviewed by Jonathan Acosta, MD · Fellowship-trained orthopaedic spine surgeon · Last reviewed October 2026

Posterolateral lumbar fusion (PLF)

What it is

A back approach in which the surgeon decompresses the nerves as needed and fuses the vertebrae by placing bone graft along the sides of the spine (over the transverse processes), usually held with screws and rods — without necessarily placing a spacer inside the disc space1. It's a long-established technique used for instability and certain cases of spondylolisthesis.

Lumbar interbody fusions: ALIF, TLIF, XLIF (and related approaches)

The shared idea

In an interbody fusion, the surgeon removes the disc and places a spacer (cage) inside the disc space between the two vertebral bodies, then allows bone to grow through and across it. Because the spacer sits in the disc space itself, interbody fusion can restore disc height, open up the nerve openings indirectly, and rebuild the natural curve (lordosis) of the low back. The different "letters" simply describe the direction the surgeon approaches the spine from — and that choice is highly patient-specific, depending on which level is involved, your anatomy, prior surgeries, body shape, blood vessel and nerve positions, and the specific goals of the operation1.

There is no single "best" interbody approach. Studies comparing them generally show similar clinical outcomes, and the right choice is individualized — guided by your anatomy, the level being treated, the amount of correction needed, and the surgeon's judgment and experience1. Each route trades one set of advantages for a different set of risks:

Approach Direction of approach Main advantages Main trade-offs / risks Often chosen when
ALIF (anterior) Through the front (abdomen), between the large blood vessels Removes the whole disc; allows the largest spacer and best restoration of disc height and lordosis; spares the back muscles Requires navigating around major blood vessels and abdominal organs; rare risk of vessel injury or, in men, retrograde ejaculation Rebuilding disc height / curve, especially at the lowest levels (L5–S1); alignment correction1
TLIF (transforaminal, posterior) From the back, through one side via the nerve-root tunnel (foramen) Lets the surgeon decompress the nerves directly and fuse from one incision; less nerve pulling than older posterior methods Involves some retraction near nerves; smaller cage than anterior/lateral routes Nerve compression needing direct decompression and fusion; revision surgery
XLIF / LLIF (lateral) From the side, through a small incision, passing through the psoas muscle Minimally invasive; large cage for good height/curve restoration; avoids both the abdominal organs and the back muscles Passes near the nerves of the lumbar plexus in the psoas muscle (temporary thigh numbness/weakness can occur); hard to reach the lowest level (L5–S1) Multilevel degeneration, scoliosis correction, when a large cage is needed1

You may also hear of OLIF (oblique, a variation that approaches from the side-front, in the corridor between the psoas muscle and the blood vessels) and PLIF (a traditional posterior interbody fusion, less common now because it requires more nerve retraction than TLIF). Sometimes the front and back approaches are combined (a "360-degree" fusion) when both maximal correction and strong posterior fixation are needed1.

Sources

  1. Talia AJ, et al. Comparison of the different surgical approaches for lumbar interbody fusion. Journal of Clinical Neuroscience. 2015. PubMed

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